"Expert opinion: Cardiovascular pathology significantly contributes to worse clinical and MRI-derived disease outcomes in MS. Global and regional cerebral hypoperfusion may be associated with poorer physical and cognitive performance. Prevention, improved detection, and treatment of the cardiovascular-based pathology may improve the overall long-term health of MS patients."

https://www.tandfonline.com/doi/abs/10.1080/14737175.2019.1610394?journalCode=iern20

Vascular Aspects of Multiple Sclerosis: Emphasis on Perfusion and Cardiovascular Comorbidities. Expert Review of Neurotherapeutics. Accepted 18 April 2019.