Magnesium Sulfate Protects Against the Bioenergetic Consequences of Chronic Glutamate Receptor Stimulation

"...Overall, our studies show that a clinically pharmacologic MgSO4 concentration protects against a loss of neuronal mitochondrial spare respiratory capacity caused by chronic, endogenous glutamate receptor stimulation. In addition, MgSO4 improves the ability of mitochondria to respond to an increase in energy demand elicited by a subsequent excitotoxic concentration of glutamate. Optimization of a protocol for delivering MgSO4 across the blood-brain-barrier holds promise for the protection of neurons from stroke, cardiac arrest, traumatic brain injury, or subarachnoid hemorrhage-induced metabolic failure..." http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827425/


Magnesium Sulfate Protects Against the Bioenergetic Consequences of Chronic Glutamate Receptor...
www.ncbi.nlm.nih.gov
We tested the hypothesis that magnesium sulfate (MgSO 4 , 3 mM) protects against metabolic failure caused by excitotoxic glutamate exposure.