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Wednesday, January 17, 2018 11:20 PM | Venöse Multiple Sklerose, CVI & SVI, CCSVI Volg link
Effect of magnesium deficiency on ultrastructural changes in coronary arteries of swine., Acta Pathol Jpn. 1986

Abstract
The effects of magnesium (Mg) deficiency on the coronary arteries of 27 Yorkshire swine were studied by light and electron microscopy. The experimental animals were divided into 4 groups which received the following supplements: Group I, basal ration with adequate Mg (540 mg/kg diet), Group II, basal ration with insufficient Mg (270 mg/kg diet) Group III, 10% milk powder with adequate Mg (540 mg/kg diet), Group IV, 10% milk powder with insufficient Mg (270 mg/kg diet). Serum analysis indicated that dietary low Mg supplementation decreased cholesterol levels and increased phospholipid concentrations significantly. The highest magnitude and incidence of intimal thickening were observed in the coronary arteries of Group IV (p less than 0.003). No significant intimal thickening was detected in any of the other groups. Ultrastructural studies revealed a greater frequency of degenerated cells in Group III and IV (p less than 0.01). Numerous calcifications were observed in only Group IV. These data suggest that moderate Mg deficiency can promote atherosclerosis in combination with some atherogenic diet, and that the presence of smooth muscle cell degeneration is important in order for a magnesium deficiency to exert an effect on the coronary artery of swine. https://www.ncbi.nlm.nih.gov/pubmed/3705959
Venöse Multiple Sklerose, CVI & SVI, CCSVI
Wednesday, January 17, 2018 11:20 PM | DIRECT-MS shared MS Hope's post. Volg link

MS Hope
Landmark Cinemas Canada is hosting screenings of Matt Embry's documentary Living Proof February 03-05!

Saturday Feb. 03, 2018 1 p.m.
Sunday Feb. 04, 2018 1 p.m.
Monday Feb. 05, 2018 7 p.m.

Surrey - Landmark Cinemas 12 Guilford
GTA - Landmark Cinemas 24 Whitby
Ottawa - Landmark Cinemas 24 Kanata
Calgary - Landmark Cinemas 16 Country Hills
Edmonton - Landmark Cinemas 9 City Centre

TICKETS
Available soon @ https://www.landmarkcinemas.com/film-info/living-proof
Wednesday, January 17, 2018 6:15 PM | The Vascular Connection to Multiple Sclerosis Volg link
Dr. Jonathan Kipnis--whose lab changed all we thought we knew by discovering the brain's lymphatic vessels-- has presented his new theory on how the immune system works. And it's pretty spectacular. #MSisNotEAE #TheSeventhSense #ModulateDontAblate
Immune system: The “seventh sense”
The brain is our computing machine that integrates stimuli from the environment and orchestrates responses to these stimuli. Here, I propose that the defining role of the immune system is to sense microorganisms and to inform the brain about them.
Wednesday, January 17, 2018 12:30 AM | The Vascular Connection to Multiple Sclerosis Volg link
Our family has been using the VSL3 probiotic for years, as part of The Endothelial Health Program. Nice to finally see MS researchers considering the anti-inflammatory affect of probiotics! "These findings suggest that the use of probiotic VSL3 can induce changes in the gut microbiota composition that are associated with an anti-inflammatory peripheral innate immune response in controls and MS patients."
Investigation of probiotics in multiple sclerosisMultiple Sclerosis Journal - Stephanie K Tankou, Keren Regev, Brian C Healy, Laura M Cox, Emily Tjon, Pia Kivisakk, Isabelle P Vanande, Sandra Cook, Roopali Gandhi, Bonnie Glanz, James Stankiewicz,...
None of the disease-modifying therapies (DMTs) currently being used for the management of multiple sclerosis (MS) are 100% effective. In addition, side effects ...
Tuesday, January 16, 2018 12:36 AM | CCSVI Alliance shared The Vascular Connection to Multiple Sclerosis's post. Volg link

The Vascular Connection to Multiple Sclerosis
Extracranial venous angioplasty is ineffective to treat MS
Robert Zivadinov and Bianca Weinstock-Guttman
A randomized, double-blind, sham-controlled trial, Brave Dreams, has shown no clinical or radiological benefit of percutaneous transluminal angioplasty (PTA) to correct chronic cerebrospinal venous insufficiency in patients with multiple sclerosis (MS). These results finally settle the scientific debate over whether PTA can improve clinical, radiological and symptomatic outcomes in this patient population.
https://drive.google.com/file/d/1MK_GoINZevgSMXxu12R1VqP6A6CWc0Ym/view?usp=sharing
Saturday, January 13, 2018 6:30 PM | Venöse Multiple Sklerose, CVI & SVI, CCSVI Volg link
Magnesium Deficiency a Public Health Crisis

“Subclinical magnesium de ciency: a principal driver of cardiovascular disease and a public health crisis, Open Heart 2018

Abstract

Because serum magnesium does not reflect intracellular magnesium, the latter making up more than 99% of total body magnesium, most cases of magnesium deficiency are undiagnosed. Furthermore, because of chronic diseases, medications, decreases in food crop magnesium contents, and the availability of refined and processed foods, the vast majority of people in modern societies are at risk for magnesium deficiency. Certain individuals will need to supplement with magnesium in order to prevent suboptimal magnesium defciency, especially if trying to obtain an optimal magnesium status to prevent chronic disease. Subclinical magnesium deficiency increases the risk of numerous types of cardiovascular disease, costs nations around the world an incalculable amount of healthcare costs and suffering, and should be considered a public health crisis. That an easy, cost-effective strategy exists to prevent and treat subclinical magnesium deficiency should provide an urgent call to action....”
Learn more/full paper: http://openheart.bmj.com/content/openhrt/5/1/e000668.full.pdf
Venöse Multiple Sklerose, CVI & SVI, CCSVI
Thursday, January 11, 2018 11:22 PM | CCSVI Alliance Volg link
Posted online Jan. 11, 2018 in Neurology Today
"In the Clinic-Multiple Sclerosis: Randomized Clinical Trial Finds Venous Angioplasty Ineffective for MS"

Quote from Dr. Zamboni “I would continue to investigate the hypothesis of the value of cerebral drainage in MS pathogenesis, but further studies on this technique are not needed.” (Let's hope that neurologists will further research the fluid dynamics in the MS cranial vault - CCSVI Alliance)
http://journals.lww.com/neurotodayonline/Fulltext/2018/01110/In_the_Clinic_Multiple_Sclerosis__Randomized.9.aspx
In the Clinic-Multiple Sclerosis: Randomized Clinical Trial ... : Neurology Today
An abstract is unavailable.
Wednesday, January 10, 2018 6:11 PM | The Vascular Connection to Multiple Sclerosis Volg link
Extracranial venous angioplasty is ineffective to treat MS
Robert Zivadinov and Bianca Weinstock-Guttman
A randomized, double-blind, sham-controlled trial, Brave Dreams, has shown no clinical or radiological benefit of percutaneous transluminal angioplasty (PTA) to correct chronic cerebrospinal venous insufficiency in patients with multiple sclerosis (MS). These results finally settle the scientific debate over whether PTA can improve clinical, radiological and symptomatic outcomes in this patient population.
https://drive.google.com/file/d/1MK_GoINZevgSMXxu12R1VqP6A6CWc0Ym/view?usp=sharing
zivadinov18.pdf
Wednesday, January 10, 2018 5:53 PM | The Vascular Connection to Multiple Sclerosis Volg link
New approaches involving completely different pathogenic mechanisms in neurological diseases are rarely discovered. #CCSVI represented a new hypothesis to attempt to explain the pathogenesis of MS.
https://twitter.com/zambo57/status/950799891785187329
Paolo Zamboni on Twitter
“New approaches involving completely different pathogenic mechanisms in neurological diseases are rarely discovered. #CCSVI represented a new hypothesis to attempt to explain the pathogenesis of MS. https://t.co/dTghHVJYrk
Wednesday, January 10, 2018 5:51 PM | The Vascular Connection to Multiple Sclerosis Volg link
The relative inefficiency of a surgical technique does not mean that #CCSVI theory should be rejected in #multiplesclerosis. A comment on Nat. Rev. Neurol.
https://twitter.com/zambo57/status/950681251077292034
Paolo Zamboni on Twitter
“The relative inefficiency of a surgical technique does not mean that #CCSVI theory should be rejected in #multiplesclerosis. A comment on @NatRevNeurol https://t.co/ZwgADf1uAf
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