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Wednesday, May 24, 2017 4:11 AM | Venöse Multiple Sklerose, CVI & SVI, CCSVI added 2 new photos. Volg link
Excess Iron Causes Calcification, by Morley Robbins

Iron Toxicity Post #58: Toto is my HERO!...

One of my ALL-TIME favorite movie scenes is the climax in “The Wizard of OZ,” when Toto pulls back the Green Curtain to reveal the TRUTH that the so-called “Wizard” is merely the “snake-oil salesman” from the opening scenes of this delightful cinematography gem…

That scene is what inspires me daily, and has for the past 8+ yrs, to dig deeper & deeper for the truth of what ails us. Please take a moment to refresh your memory of this captivating & symbolic scene:
https://www.youtube.com/watch?v=NZR64EF3OpA

And please know that ALL of that digging is beginning to REALLY pay off!

This week’s scientific discovery is simply AMAZING!

I would ask each of you to read it from stem to stern. It’s a STUNNER that connects MANY of the dots that we’ve been discussing, exploring, & debating lo’ these last few years as we’ve sought to understand the ORIGIN of ALL of this metabolic dysfunction that stems from mineral dysregulation, but often gets labeled “medical disease” because NO ONE thought to challenge or question the veracity of the Great & Powerful OZ!!!...

Please take a moment and spend some time with this BLOCKBUSTER Study:
Valenti, et al, 2011, “Serum Hepcidin & Macrophage Iron Correlate With MCP-1 Release & Vascular Damage” http://atvb.ahajournals.org/conte…/atvbaha/…/3/683.full.pdf…

In my humble opinion, this article is a MAJOR SMOKING GUN!...

This is an illuminating study in HOW Arterial Plaque becomes a REALITY in Arterial tissue due to Iron laden Macrophages and the Inflammatory process that they initiate. In effect, what this Study is revealing is the EXACT process of how Iron stimulates Inflammation and KEY chemical agents in that inflammatory process that are DIRECTLY involved in the process of CALCIFYING the artery wall. It is VERY specific to the inherent nature of Iron, and it is a VERY deadly process that affects millions of people ALL over the Planet.

My favorite quotation:
“MCP-1, [Monocyte Chemoattactant Protein-1, aka CCL-2], is a chemokine involved in Macrophage recruitment at Inflammation sites. MCP-1 is released by Macrophages, but also by smooth muscle cells and endothelial cells, and
plays a crucial role in the both the initiation and progression of atherosclerosis, and MCP-1 levels reflect the atherosclerotic plague burden”

Let me translate… This indicates yet ANOTHER role that Iron plays to ACTIVATE THE CALCIFICATION of soft tissue… There are others, esp. the activation of Hepatic Stellate Cells, as well as the creation of intracellular Endoplasmic Reticulum Stress that releases stored Calcium into the cell/cytoplasm effectively killing optimal cellular function.

Yes, excess Iron CAUSES Calcification. It is WELL researched & documented in research labs all over the Globe.

So, again, it’s important that we FULLY understand how does Iron build up in the Macrophages to cause this phenomenon?!? You may recall that this was the focus of a recent Post on Iron Toxicity (#56) earlier this month…
Let’s review… There are THREE ways that Iron is the CAUSATIVE agent in creating Inflammation:

o Directly: Iron, in and of itself, can cause an Inflammatory response;
o Indirectly: As Iron builds, it attracts Bacteria that give off an Endotoxin called Lipopolysaccharide (LPS) that are HIGHLY KNOWN to stimulate the Inflammatory cascade; and again
o Indirectly: As Iron builds, it stimulates the production & release of Hepcidin, the 25-Amino Acid peptide involved in Iron homeostasis, that is ALSO known to CAUSE an Inflammatory response.

It is safe to say that excess, unbound Iron CAUSES Inflammation. This is an important bedrock mineral understanding in your efforts to STOP this insidious metabolic process.

And while the THREE factors noted above ^^^^ are an IRON-ic & circular process, the excess, unbound Iron is the VERY AGENT to CAUSE the release of the Hepcidin Hormone that KEEPS THE IRON INSIDE THE MACROPHAGE… This is outlined in the next quotation:

“Hepcidin, induced by Iron and Inflammation, acts to BLOCK [emphasis added] Iron REcycling from Macrophages by binding and causing internalization and degradation of Ferroportin, the sole Iron exporter.”

Of course, this article is SILENT on the role of Ceruloplasmin Oxidase, aka, FERROXIDASE that is central to the Ferroportin-driven process of Iron egress that was explored extensively in Iron Toxicity Post #56… And we are learning, that this GAP in understanding the FULL role of Ceruloplasmin is a major factor in WHY soooooo many are suffering from Iron overload conditions, but yet are being deemed “Anemic…” Regrettably, this label is a CLASSIC case of myth-taken identity, and these conditions are in reality, “Anemia of Chronic Inflammation,” a condition which calls for MORE Bioavailable Copper, and NOT Mo’ Iron!

In several prior Posts on Iron Toxicity, we learned that Iron is THE mineral agent that CAUSES Calcium LOSS in the Bone Matrix, I.e. HARD TISSUE, (Jian, 2009) by BOTH stimulating the action of OsteoClasts via the activation of Acid Phosphatase enzyme, but Iron ALSO blunts the action of the OsteoBlasts, the bone builder cells… This is a stunning role for excess, unbound Iron to play, esp. in the aging body.
And now we learn from this study by Valenti et al (2011) yet ANOTHER compelling revelation that Iron CAUSES Calcification BUILD-UP in the arteries (and organs, as we’ll see momentarily…), i.e. in the SOFT TISSUES of the body… And what Valenti et al reveals is that either Iron and/or Hepcidin has the ability to stimulate the release of MCP-1 to fulfill this Calcification process within the tissue.

And as I became more familiar with this Inflammatory agent, MCP-1, I began to realize that this Pro-Inflammatory chemical is involved in a similar Calcification process ALL OVER THE BODY. (NOTE, Please STOP for a moment, take a deep breath, RE-READ that sentence AGAIN, and allow yourself to process the ENORMITY of this ^^^^ metabolic
TRUTH…)

To drive this Iron-induced Calcium formation point home, here are a series of articles that PROVE the role of MCP-1 in stimulating and activating the Calcification of soft tissue and organs. And yes, it is IRON that is at the VERY EPICENTER of this metabolic mayhem. Again, mind you, the conditions noted below are NOT medical disease.

And there is COMPELLING linear feet of research to PROVE JUST THAT. These are but a sampling of the thousands of studies on this topic alone! (Studies that either your favorite M.ineral D.enialist doesn’t know about, or doesn’t want you to know about… -- which is the GREATER sin?!?...)

KIDNEY STONES: Umekawa, et al, 2002, “Oxalate ions and calcium oxalate crystals stimulate MCP-1 Expression in renal epithelial cells”
http://www.kidney-international.com/…/S0085-2538(15)481…/pdf

KIDNEY STONES: Lloyd, CM et al, 1997, “Role of MCP-1 and RANTES in inflammation and progression to fibrosis during murine crescentic nephritis”
https://www.ncbi.nlm.nih.gov/m/pubmed/9365123/

LIVER STONES: Seki, et al, 2009, “CCR2 [aka, MCP-1] promotes hepatic fibrosis in mice” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705470/

GALL BLADDER STONES: Maurer, et al, 2009, “Roles of Infection, Inflammation, and the Immune System in Cholesterol Gallstone Formation” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774219/

CATARACTS OF THE EYE: Zhu et al, 2016, “Proinflammatory status in the Aqueous Humor of High Myopic Cataract Eyes”
https://www.ncbi.nlm.nih.gov/m/pubmed/25805322/

For those that are inclined to DIG a little deeper, please look for the role that MCP-1 plays in these – and OTHER tissues around the body. Now you BETTER understand that it’s Iron and Iron-stimulated agents that are CAUSING the rise of MCP-`1, which is THEN CAUSING this process of Calcification.

Please NOTE: this excess Calcium is NOT coming from Mars!... This excess Calcium is NOT a medical disease!... This excess Calcium is being CREATED by the actions of excess, unbound Iron. And that’s a Metabolic FACT!

And lest you forgot, please take the time to refresh your understanding of the role that Iron plays in the FLIP SIDES of Metabolic CHAOS:
Oxidative Stress, and Inflammation: Messner et al, 2013, “Iron overload causes oxidative stress” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700657/

So, ONCE AGAIN, that’s a lot of blah, blah, blah… I truly wish is didn’t take soooo much time & effort to explain these vital activities and actions of minerally-deranged tissue.

And in the immortal words of the famed newscaster, Paul Harvey, “Now you know the rest of the story!” And were Toto able to speak, I’m quite confident that that is EXACTLY what s/he would say…

I trust this latest Post will shed important NEW light on how Iron is a CENTRAL & CAUSAL agent in every conceivable condition that we are taught to fear & medicate. And for those of us steeped in the Root Cause Protocol, we know that we are engaged in a simple and directed process to REVERSE this IRON-ic metabolic process.

A votre sante!

Morley Robbins
gotmag.org

https://www.facebook.com/groups/MagnesiumAdvocacy/permalink/1361582807243118/
Photos from Venöse Multiple Sklerose, CVI & SVI, CCSVI's post
Tuesday, May 23, 2017 8:24 PM | CCSVI Alliance Volg link
Although the research is looking at stroke and seizures, it seems plausible that it could be a component in neurological disease.

"Researchers connect brain blood vessel lesions to intestinal bacteria"
https://www.nih.gov/news-events/news-releases/researchers-connect-brain-blood-vessel-lesions-intestinal-bacteria

(The NINDS is the nation’s leading funder of research on the brain and nervous system. The mission of NINDS is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease.)
Researchers connect brain blood vessel lesions to intestinal bacteria
NIH-funded pre-clinical study links gut microbes and the immune system to a genetic disorder that can cause stroke and seizures.
Tuesday, May 23, 2017 6:07 PM | CCSVI in Multiple Sclerosis shared Canadian Neurovascular Health Society's photo. Volg link
From Canadian Neurovascular Health Society--
"Neuroplasticity is vital for maintenance and improvement of function in those with neurodegenerative diseases, like MS. One way to stimulate neuroplasticity is through transcranial direct current stimulation. The following study shows promising results in improvement of fatigue in MS patients using transcranial direct current stimulation at home with remote supervision."
http://neurology.org/content/88/16_Supplement/P3.343.short
To find out more about transcranial direct current stimulation, see: http://www.hopkinsmedicine.org/…/brain_stimulation/tdcs.html
Canadian Neurovascular Health Society
Neuroplasticity is vital for maintenance and improvement of function in those with neurodegenerative diseases, like MS. One way to stimulate neuroplasticity is through transcranial direct current stimulation. The following study shows promising results in improvement of fatigue in MS patients using transcranial direct current stimulation at home with remote supervision.

http://neurology.org/content/88/16_Supplement/P3.343.short

To find out more about transcranial direct current stimulation, see: http://www.hopkinsmedicine.org/psychiatry/specialty_areas/brain_stimulation/tdcs.html
Tuesday, May 23, 2017 4:19 AM | CCSVI Alliance Volg link
Prayers for our friends in Manchester and all of England.
Timeline Photos
Monday, May 22, 2017 1:16 AM | CCSVI in Multiple Sclerosis shared CCSVI Alliance's post. Volg link
Sunday, May 21, 2017 11:35 PM | CCSVI Alliance Volg link
Update research on the brain lymphatic and glymphatic systems

https://www.washingtonpost.com/national/health-science/when-scientists-saw-the-mouse-heads-glowing-they-knew-the-discovery-was-big/2017/05/19/f33cc574-246a-11e7-a1b3-faff0034e2de_story.html?utm_term=.96df9e0fc6d9
When scientists saw the mouse heads glowing, they knew the discovery was big
Finding the brain’s lymphatic system overturned more than 300 years of accepted wisdom.
Saturday, May 20, 2017 11:57 PM | CCSVI Alliance Volg link
New Biomarkers For Multiple Sclerosis Pathogenesis
http://neurosciencenews.com/multiple-scleosis-pathogensis-6730/

CCSVI Alliance asks: ....why not test for these biomarkers pre and post treatment (whether it be pharmaceutical, or other intervention including vascular) to measure change in level of CSF solutes?
New Biomarkers For Multiple Sclerosis Pathogenesis
Researchers identify new biomarkers associated with multiple sclerosis pathogenesis.
Thursday, May 18, 2017 7:21 PM | CCSVI Alliance Volg link
Joan Beal writes about endothelial dysfunction in MS. http://ccsviinms.blogspot.com/2017/05/ms-is-vascular.html

CCSVI Alliance additional notes:
Authored by Dr Alexander & Dr Minagar "Emerging Roles of Endothelial Cells in Multiple Sclerosis Pathophysiology and Therapy"
Quote: "Basic scientific and clinical studies now support contributions of vascular and endothelial cell stress and apoptosis as significant features of MS and help explain how blockade of leukocyte binding and transendothelial extravasation of activated immune cells across the MS-inflamed cerebral microvasculature and restitution of endothelial barrier function represent important goals of MS treatment. Such approaches can achieve significant reductions in MS disease activity and progression, but carry risks from interference with immune surveillance".

Disorders, habits and unavoidable life events (trauma, structural/mechanical abnormalities) can contribute to endothelial dysfunction. https://www.verywell.com/endothelial-dysfunction-1746344
MS is vascular
MS is caused by a breakdown of cerebral endothelial cells. The loss of these vascular cells, which line all 60,000 miles of our blood and ...
Wednesday, May 17, 2017 10:36 PM | Venöse Multiple Sklerose, CVI & SVI, CCSVI Volg link
Magnesium Deficiency Symptoms – What You Need to Know, by Dr Perlmutter

See more at: http://www.drperlmutter.com/magnesium-deficiency-symptoms-causes-treatments/#sthash.UIWCnnJH.dpuf
Magnesium Deficiency Symptoms - What You Need to Know - Dr. Perlmutter
Wednesday, May 17, 2017 5:08 PM | CCSVI in Multiple Sclerosis Volg link
MS is vascular
MS is vascular
MS is caused by a breakdown of cerebral endothelial cells. The loss of these vascular cells, which line all 60,000 miles of our blood and ...
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