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Tuesday, November 13, 2018 3:30 AM | The Vascular Connection to Multiple Sclerosis Volg link
Paolo Zamboni shared this news story on twitter. Yes, blood flow matters to brain health. We've known it all along. #HeartBrainConnection Maybe they'll look at the veins?
Neck scan 'can spot early dementia signs'
Scientists hope the test may offer a new way to spot those at risk of dementia, before symptoms show.
Monday, November 12, 2018 7:40 PM | Venöse Multiple Sklerose, CVI & SVI, CCSVI Volg link
Is there more to learn about functional vitamin D metabolism? - YES, of course!

“• Narrow band of UV light (305–315 nm) suppresses EAE independent of vitamin D.”

Learn more and get your nanometer pills on start! ;)
https://www.sciencedirect.com/science/article/abs/pii/S096007601400199X

p.s. Nanometer/nm is a unit of length in the metric system, equal to one billionth of a metre.
Is there more to learn about functional vitamin D metabolism?
The state of information on the enzymes responsible for the conversion of vitamin D3 to 1a,25-dhydroxyvitamin D3 (1,25-(OH)2D3), the metabolic active …
Saturday, November 10, 2018 2:05 AM | The Vascular Connection to Multiple Sclerosis shared Canadian Neurovascular Health Society's post. Volg link

Canadian Neurovascular Health Society
Ocular research showing differences between persons with MS and healthy controls in blood flow velocities:

https://eandv.biomedcentral.com/articles/10.1186/s40662-018-0123-0
Friday, November 9, 2018 9:45 PM | CCSVI Alliance Volg link
Published Nov. 8, 2018 in Nature...
In a study published today in Nature, researchers outline a new understanding of the biology of T cells, a type of immune cell in the body, that demonstrates how the cells can be activated to either enhance immunity against cancer or block autoimmune disease.
"As a trained immunologist who was involved in defining some of the key signaling pathways in T cells, it was truly amazing to find such a critical new player in T cell biology," added Penninger, who is also the founding director of Institute of Molecular Sciences of the Austrian Academy of Sciences. "And since it regulates not only early activation but how T cells grow, the possibilities for medical applications are extremely varied, from controlling autoimmune diseases, asthma and allergies to having a new way to trigger anti-cancer immunity."
"By targeting BH4, we are able to suppress T cell activity in inflammatory conditions and increase their activity in the case of cancer," said study co-author Woolf, director of the F.M. Kirby Neurobiology Center at Boston Children's Hospital. "The ability to target the same pathway in opposite directions is significant and represents a whole new therapeutic approach."
https://medicalxpress.com/news/2018-11-discovery-cancer-autoimmune-disease-therapy.html
https://www.nature.com/articles/s41586-018-0701-2
Novel discovery could lead to new cancer, autoimmune disease therapy
A new discovery by an international research team—co-led by UBC Canada 150 Research Chair Josef Penninger and Harvard Medical School neurobiologist Clifford Woolf—could have implications for therapies for cancer and autoimmune diseases.
Wednesday, November 7, 2018 3:59 AM | Venöse Multiple Sklerose, CVI & SVI, CCSVI Volg link
Glycosylphosphatidylinositol-anchored Ceruloplasmin Is Required for Iron Efflux from Cells in the Central Nervous System, Journal of Biological Chemistry 2003

Abstract

Ceruloplasmin (Cp) is a ferroxidase that converts highly toxic ferrous iron to its non-toxic ferric form. A glycosylphosphatidylinositol (GPI)-anchored form of this enzyme is expressed by astrocytes in the mammalian central nervous system, whereas the secreted form is expressed by the liver and found in serum. Lack of this enzyme results in iron accumulation in the brain and neurodegeneration. Herein, we show using astrocytes purified from the central nervous system of Cp-null mice that GPI-Cp is essential for iron efflux and not involved in regulating iron influx. We also show that GPI-Cp colocalizes on the astrocyte cell surface with the divalent metal transporter IREG1 and is physically associated with IREG1. In addition, IREG1 alone is unable to efflux iron from astrocytes in the absence of GPI-Cp or secreted Cp. We also provide evidence that the divalent metal influx transporter DMT1 is expressed by astrocytes and is likely to mediate iron influx into these glial cells. The coordinated actions of GPI-Cp and IREG1 may be required for iron efflux from neural cells, and disruption of this balance could lead to iron accumulation in the central nervous system and neurodegeneration.

learn more/full paper: http://www.jbc.org/content/278/29/27144.long?view=long&pmid=12743117#fn-2
Glycosylphosphatidylinositol-anchored Ceruloplasmin Is Required for Iron Efflux from Cells in the Central Nervous System
Suh Young Jeong, Samuel David
Monday, November 5, 2018 3:32 AM | Venöse Multiple Sklerose, CVI & SVI, CCSVI Volg link
Doctoring Facts: The Ugly Face Of Medical Research

„...Conclusion
Commercialization of medicine forever changed the way medicine was practiced. Somewhere along the journey from the family physician who made house calls, to the modern-day super specialist in swank 5 star hospitals, we lost track. We got even more lost when scientists worked hand in glove with industry giants who finance mega research projects. The integrity and objectivity of such studies is anybody’s guess.

It is heartening to note that in the midst of this anarchy we still have doctors who have not sold their soul to the mercenaries. These are the brave-hearts who have the audacity to question authority, the spine to stand with the truth and the conviction to lend their voice to causes they believe in. Hope may not be quite dead…

In this digital age information is available at your fingertips. Ivory towers are coming crashing down and knowledge is no longer the prerogative of a select few. The wisdom of the crowd is enabling people to engineer their own health. False propaganda and vested interests will no longer get a foothold in mass consciousness. People have woken up to the fact that the health care industry prioritizes bottom-lines over everything else...“

https://www.dlife.in/news-and-research-articles-on-diabetes-obesity-lipids/doctoring-facts-the-ugly-face-of-medical-research/?fbclid=IwAR0xVMuSwUvIC7LvG7nAmVf82VlgvG7Se5b2_mqVReWJ0gU3fAWI0h_Vzds
Doctoring Facts: The Ugly Face Of Medical Research | dLife.in
I am inherently sceptical of everything that mainstream experts have to say about diet, diabetes and drugs. Nothing unusual there. Why so?
Sunday, November 4, 2018 7:16 PM | The Vascular Connection to Multiple Sclerosis Volg link
Again, iron accumulation leads to increased disability in Multiple Sclerosis.

Brain Iron at Quantitative MRI Is Associated with Disability in Multiple Sclerosis.
Conclusion Quantitative susceptibility mapping (QSM) suggests that altered deep gray matter iron is associated with the evolution of multiple sclerosis (MS) and on disability accrual, independent of tissue atrophy.
https://www.ncbi.nlm.nih.gov/pubmed/30015589
Brain Iron at Quantitative MRI Is Associated with Disability in Multiple Sclerosis. - PubMed - NCBI
Radiology. 2018 Nov;289(2):487-496. doi: 10.1148/radiol.2018180136. Epub 2018 Jul 17.
Saturday, November 3, 2018 6:35 AM | Venöse Multiple Sklerose, CVI & SVI, CCSVI added 2 new photos. Volg link
To the NZ followers -Today I met the ‘New Zealand Hemp Brokers‘ at the Green Living Show in Auckland in person and I want to share their website address with you. They are lovely people who are selling great products based on CBD oil!! ?? Arne
https://www.facebook.com/pg/New-Zealand-Hemp-Brokers-1619048218317302/reviews/?ref=page_internal
Photos from Venöse Multiple Sklerose, CVI & SVI, CCSVI's post
Friday, November 2, 2018 6:59 PM | CCSVI Alliance Volg link
Summary: Researchers have discovered how the nature of T cells help protect the brain from viruses. The findings shed light on the role the immune system plays in a number of neurodegenerative disorders.
https://neurosciencenews.com/immune-cells-brain-10136/

(The full report "Tissue-resident memory T cells populate the human brain" is open access and can be found at: https://www.nature.com/articles/s41467-018-07053-9)
Nature of Immune Cells in Brain Discovered
Researchers have discovered how the nature of T cells help protect the brain from viruses. The findings shed light on the role the immune system plays in a number of neurodegenerative disorders.
Wednesday, October 31, 2018 11:45 PM | Venöse Multiple Sklerose, CVI & SVI, CCSVI Volg link
- The Human Magnesome –
Just a little reminder what it means for our bodies to be low in Magnesium. It’s like trying to play beautiful sinfonie by one of mankind’s greatest composers without a conductor. IT’S NOT GOING TO WORK! No matter how hard the individual of the orchestra tries to play his part perfectly. Without a conductor, the sinfonie will end up as a BIG MESS!

The human "magnesome": detecting magnesium binding sites on human proteins., BMC Bioinformatics2012

Full paper: https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-13-S14-S10
“...CONCLUSION: We describe and deliver the "human magnesome", a set of proteins of the human proteome that inherit putative binding of magnesium ions. With our BAR-hMG, 251 clusters including 1,341 magnesium binding protein structures corresponding to 387 sequences are sufficient to annotate some 13,689 residues in 3,751 human sequences as "magnesium binding". Protein structures act therefore as three-dimensional seeds for structural and functional annotation of human sequences. The data base collects specifically all the human proteins that can be annotated according to our procedure as "magnesium binding", the corresponding structures and BAR+ clusters from where they derive the annotation (http://bar.biocomp.unibo.it/mg).
Venöse Multiple Sklerose, CVI & SVI, CCSVI
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