Another study basically concluding “lesions don’t matter.“ When will more researchers shift their priorities to other than watching lesions?

Acute multiple sclerosis lesion pathology does not predict subsequent clinical course—a biopsy study

Conclusion

Uniform white matter subacute demyelination is associated with a diverse clinical course ranging from a monophasic illness to progressive MS, suggesting that extraneous factors distinct from the basic pathology significantly influence the clinical course in MS.

https://link.springer.com/article/10.1007/s11845-019-01983-z