Diagnosis, phenotypes, and variants of MS and related disorders



Factors that determine MS susceptibility, disease course, and prognosis: The roles and interactions of genetics, epigenetics, the microbiome, environmental factors, pregnancy, age, comorbidities, and risk behaviors in determining MS susceptibility and disease course



Pathogenesis of MS relapses and progression: the link between inflammation and neurodegeneration



Mechanisms, detection, and significance of gray matter pathology in MS



Methods to monitor MS disease activity and severity: Patient self-report and automated self-assessment, new clinician-reported outcomes, standard and advanced imaging, and biomarkers



Current, emerging, and future disease therapies for relapsing-remitting and progressive MS and related disorders



Treatment strategies: Early treatment, switching therapies, treating-to-target of no evidence of disease activity, personalized treatment, and post-marketing monitoring of safety and efficacy



Regeneration and repair: which strategies look promising and how do we test them



Aspects of trial design in relapsing and progressive MS



Rehabilitative strategies to restore function: Improving cognition, motor function, and mobility



Management of the symptoms and other sequelae of MS



Society and MS: roles of the expert patient, social media, and health policy