The ISNVD is dedicated to the dissemination and review of new concepts in etiopathogenesis, novel diagnostics and modes of therapeutic treatment in the diseases of the neurovasculature.
Cardiovascular risk factors, Meniere disease, endothelial dysfunction, sinus venous stenosis are just a few of the topics to be presented in Naples at the ISNVD Conference March 27-29, 2015. As Dr. Michael Dake noted in the recent Alliance video interview, there is a broadening of the program this year. He mentions that in order to understand what is going on, you need basic science to explain the range of symptoms and associations when there is venous outflow obstruction. There also needs to be a broader area of study to include all neurological disease patterns. (Please read CCSVI Alliance's discussion on other neurological diseases - OND's ).
(CCSVI Alliance would like to thank the ISNVD Executive Board for the early release of presentation abstracts from Drs. Zvadinov and Alexander. Summary of abstract material is in italics)
Robert Zvadinov
Dr. Robert Zvadinov begins the Saturday morning session with his discussion on cardiovascular risk factors and neurodegenerative disorders.
In a prospective study of 326 relapsing-remitting and 163 progressive MS patients, 61 patients with clinically isolated syndrome and 175 age-, sex- and race-matched healthy controls, Dr. Zvadinov investigated the prevalence and association of cardiovascular risk factors including hypertension, heart disease, smoking, overweight/obesity and type 1 diabetes with MRI outcomes in neurodegenerative disorders. He found that patients with neurodegenerative disorders, like MS who present with one or more CV risks showed increased lesion burden and more brain atrophy.
In other research, Dr. Zvadinov found that heart disease (especially heart murmurs) was associated with presence of CCSVI.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028062
Steve AlexanderDr. Steve Alexander, (ISNVD Vice President) will discuss his collaborative research studying Fluid Dynamic Influences on Cerebrovascular Endothelial Activation Responses. The thin layer of cells that line the interior of blood vessels, known as the endothelium, plays a complex role in vascular biology. Dr Alexander notes in his paper:
.....alterations in blood flow and vascular shear stress* are known to induce changes in arterial/venous endothelial cells…. a role for vascular disturbances is apparent in the progression of neurological disorders, particularly in initiation and progression of inflammatory processes and potentially blood-brain barrier disturbances. Because changes in vascular shear stress have been implicated in the progression of atherosclerotic disease……we hypothesized that shear stress alterations would lead to inflammatory activation of cerebral endothelial cells…..we exposed human brain endothelial cells (hCMEC-D3) to high or low levels of non-linear shear…..we found amyloid precursor protein (APP) was basically expressed in hcMEC-D3 and was released into endothelial microparticles (EMPs) in response to high fluid shear. Similarly, the neurolymphatic marker…….was increased in both cells and EMPs in response to high fluid shear….The tight junction protein Occludin was also increased in hCMEC-D3 in response to both levels of fluid shear.
* Shear stress is the tangential force of the flowing blood on the endothelial surface of the blood vessel.
Pietro M BaveraVenous abnormalities in Meniere disease will be the topic of Dr. Pietro Maria Bavera. The doctor's study titled
Chronic cerebrospinal venous insufficiency in Meniere disease concluded that: Chronic cerebrospinal venous insufficiency might be the anatomical background, which provides a predisposing factor for the development of endolymphatic hydrops in MD patients.
Another interesting study by Bavera and posted on his blog Bilateral sudden sensorineural hearing loss and chronic venous cerebrospinal insufficiency
Additional research on Meniere disease http://www.pubfacts.com/detail/24318422/Chronic-cerebrospinal-venous-insufficiency-in-patients-with-Ménières-disease. The results obtained showed a vascular pattern of cerebrospinal venous system present in patients affected by definite Meniere. This vascular impairment significantly affects the vascular areas more directly involved in the venous drainage of the inner ear. Thus venous stasis may be considered a further pathogenetic mechanism for development of Meniere's disease.
You can help support the ISNVD 2015 Conference by contributing to CCSVI Alliance's February Matching Gift Challenge. Please share with your Facebook communities and friends.
Thank You!
CCSVI Alliance
TIME IS RUNNING OUT - ONLY 1 day REMAINING TO DOUBLE YOUR DONATION
