I sent this to Dr. Bernhard Juurlink for his comments ~ Sandra

"What is known is that the mechanical pressure of blood flowing past endothelial cells causes a signalling cascade that results in formation of nitric oxide. This mechanical pressure effect increases with increased blood pressure. This nitric oxide formed then acts on adjacent smooth muscle cells to cause vasorelaxation increasing blood flow.

Basically this research states that the initial response to greatly increased blood pressure at the level of the arterioles is increased production of hydrogen peroxide, this hydrogen peroxide then inactivates the vasodilatory function of nitric oxide (by forming peroxynitrate). The loss of nitric oxide also has an effect on mitochondria that then increase formation of hydrogen peroxide and this increased hydrogen peroxide then promotes vasodilation through unknown mechanisms. But the authors point out that this does not appear to occur in coronary vessels - furthermore, the only vessels they looked at were adipose tissue arterioles.

The important lesson here is to maintain normal blood pressure."


An Acute Rise in Intralumina... [Am J Physiol Heart Circ Physiol. 2014] - PubMed - NCBI
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