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Wednesday, December 12, 2018 7:54 AM | Venöse Multiple Sklerose, CVI & SVI, CCSVI Volg link
Copper and ceruloplasmin dyshomeostasis in serum and cerebrospinal fluid of multiple sclerosis subjects, Biochim Biophys Acta Mol Basis Dis. 2018 May

Abstract
Although many studies have been carried out in order to understand the implication of copper (Cu) in the pathogenesis of multiple sclerosis (MS), the exact role that this metal plays in the disease is not still clear. Because of the lack of information in this subject, the present study compared the serum and cerebrospinal (CSF) levels of copper in MS patients in respect to a control group, matched for age and sex, finding a significant increase of metal concentrations, in both biological fluids of MS subjects. To confirm the possible impairment of Cu metabolism, we analyzed ceruloplasmin (Cp) level and activity, seeing as this protein is an established peripheral marker in diseases associated with Cu imbalance. By comparing these two parameters between control and MS subjects, we found an increase of Cp levels, associated with a decrease in Cp activity, in the second group. By analysing these data, free copper levels were calculated, significantly increased in serum of MS subjects; the increase in free copper could be one of the predisposing factors responsible for the Cu altered levels in CSF of MS patients. At the same time, this alteration could be attributable to the inability to incorporate Cu by Cp, probably due to the high oxidative environment found in serum of MS patients. Overall, all these copper alterations may play a role in MS pathogenesis. https://www.sciencedirect.com/science/article/abs/pii/S0925443918300875
Venöse Multiple Sklerose, CVI & SVI, CCSVI
Tuesday, December 11, 2018 10:36 PM | CCSVI Alliance Volg link
The holiday season places stress on anyone dealing with a neurological disease. Here is an article discussing those awkward social situations that we like to avoid. https://www.brainandlife.org/the-magazine/article/app/14/6/21/ease-awkward-social-situations-certain-visible-symptoms-can-make-social
CCSVI Alliance
Tuesday, December 11, 2018 4:31 PM | The Vascular Connection to Multiple Sclerosis Volg link
Where is the cure for MS? As Matt Embry and George Jelinek recently wrote, neurologists have been saying "the cure" is right around the corner, any day now, we're getting closer. But they've been saying this for almost 100 years. Here's my take on "The Cure Mentality." Let me know your thoughts. Joan
The Cure Mentality
Disease organizations have walks, bike rides and a variety of fund raisers to encourage donations to "Find the Cure!" While these organiza...
Saturday, December 8, 2018 6:22 PM | Venöse Multiple Sklerose, CVI & SVI, CCSVI Volg link
‘Vitamin D: a pseudo-vitamin for a pseudo-disease , The Conversation’
Academic rigour, journalistic flair, Sep. 2018

“...It can no longer be recommended for use in other conditions; the vast majority of the positive published studies in 137 diseases were reviewed as spurious. It was widely believed that vitamin D supplements prevented cardiovascular disease, but meta-analyses and large-scale genetic MR studies have ruled this out.

Pseudo-disease
We have created another pseudo-disease that is encouraged by vitamin companies, patient groups, food manufacturers public health departments and charities. Everyone likes to believe in a miracle vitamin pill and feels “they are doing something”...”

https://theconversation.com/vitamin-d-a-pseudo-vitamin-for-a-pseudo-disease-101907
Vitamin D: a pseudo-vitamin for a pseudo-disease
Largest ever clinical study shows no benefit of vitamin D in preventing bone fractures.
Tuesday, December 4, 2018 5:18 PM | CCSVI Alliance Volg link
http://www.eurekaselect.com/167711/article?fbclid=IwAR1ZsVDuX2iu-ZHHHuhVFSL9ImRsYV6VazX12vxbDub5Po4zwRjs21SbHqw
Are Cerebral Perfusion and Atrophy Linked in Multiple Sclerosis? Evidence for a Multifactorial Approach to Assess Neurodegeneration
Background: Grey Matter (GM) atrophy has been extensively described in Multiple Sclerosis (MS) patients, while cerebral hypoperfusion has been less consist...
Sunday, December 2, 2018 4:31 PM | The Vascular Connection to Multiple Sclerosis Volg link
Recent studies have verified that people with MS have slower cerebral circulation than normal people--also called "hypoperfusion."
http://www.eurekaselect.com/167711/article?fbclid=IwAR1ZsVDuX2iu-ZHHHuhVFSL9ImRsYV6VazX12vxbDub5Po4zwRjs21SbHqw http://www.ajnr.org/content/early/2018/01/11/ajnr.A5504
Here's an explanation of hypoperfusion, for those new to this concept. https://ccsviinms.blogspot.com/2015/02/cerebral-circulation-2x-slower-in.html
Cerebral Circulation---2x slower in people with MS
A brand new blinded study has found that it takes almost twice as long for blood to flow from the heart, through the brain, and back to the ...
Sunday, December 2, 2018 6:48 AM | The Vascular Connection to Multiple Sclerosis shared Canadian Neurovascular Health Society's post. Volg link

Canadian Neurovascular Health Society
Dr. Paolo Zamboni comments on research calling CCSVI angioplasty “ineffective”:

“Evoked potentials improved from baseline respectively 6 and 15 months after vein angioplasty; QoL at 0-6 months and urodynamic, too; CCSVI Multiple Sclerosis why does the study has been negatively evaluated? “

https://www.sciencedirect.com/science/article/pii/S1388245718313683
Saturday, December 1, 2018 3:30 PM | Venöse Multiple Sklerose, CVI & SVI, CCSVI Volg link

Venöse Multiple Sklerose, CVI & SVI, CCSVI
Thursday, November 29, 2018 8:40 PM | Venöse Multiple Sklerose, CVI & SVI, CCSVI shared Canadian Neurovascular Health Society's post. Volg link
Are cerebral perfusion and atrophy linked in multiple sclerosis? Evidence for a multifactorial approach to assess neurodegeneration
Canadian Neurovascular Health Society
More support for neurovascular connections to multiple sclerosis [Abstract only]

http://www.eurekaselect.com/167711/article
Thursday, November 29, 2018 7:20 PM | The Vascular Connection to Multiple Sclerosis shared Canadian Neurovascular Health Society's post. Volg link

Canadian Neurovascular Health Society
More support for neurovascular connections to multiple sclerosis [Abstract only]

http://www.eurekaselect.com/167711/article
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