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Thursday, March 21, 2019 8:37 PM | Venöse Multiple Sklerose, CVI & SVI, CCSVI Volg link
Magnesium Deficiency in Multiple Sclerosis

The MS-Magnesium Connections

Symptoms of MS that are also symptoms of magnesium deficiency include muscle spasms, weakness, twitching, muscle atrophy, an inability to control the bladder, nystagmus (rapid eye movements), hearing loss, and osteoporosis. People with MS have higher rates of epilepsy than controls. Epilepsy has also been linked to magnesium deficiencies... learn more: http://www.nhfw.info/magnesium.html
Multiple Sclerosis and Magnesium Deficiency
Reviews studies linking magnesium deficiency as a factor in MS.
Thursday, March 21, 2019 8:30 PM | Venöse Multiple Sklerose, CVI & SVI, CCSVI Volg link
Why 80% of Us Are Deficient In Magnesium

„...Symptoms of MS that are also symptoms of magnesium deficiency include muscle spasms, weakness, twitching, muscle atrophy, an inability to control the bladder, nystagmus (rapid eye movements), hearing loss, and osteoporosis. People with MS have higher rates of epilepsy than controls. Epilepsy has also been linked to magnesium deficiencies...“ learn more: http://www.greenmedinfo.com/blog/magnesium-deficiency-symptoms-and-diagnosis?fbclid=IwAR1PoMxOVpw6Nvm8tbfuK2vlCOplbmESmIECB5J2OTD0kIJ_8VFKGJ1Zz7w
Why 80% of Us Are Deficient In Magnesium
Magnesium deficiency is often misdiagnosed because it does not show up in blood tests – only 1% of the body's magnesium is stored in the blood
Thursday, March 21, 2019 7:24 PM | Venöse Multiple Sklerose, CVI & SVI, CCSVI shared a post. Volg link
Robust regional cerebral blood flow perfusion deficits in relapsing-remitting multiple sclerosis patients with executive function impairment. Hellenic Journal of Nuclear Medicine Jan 2019

Abstract
OBJECTIVES:Cognitive impairment is present in up to 65% of Relapsing Remitting Multiple sclerosis (RRMS) patients and can be extremely debilitating. Although deficits in episodic memory and processing speed occur more frequently than executive deficits, executive dysfunction tends to have a significant impact on MS patients' ability to generate strategies, think divergently, solve and estimate problems, and reason in abstract terms with substantial negative impacts on activities of daily living. In the present study we investigated perfusion detection rate and pattern, as well as the association between perfusion rates and cognitive dysfunction in cognitively impaired RRMS patients. METHODS:We present findings from 17 cognitively impaired RRMS patients who were evaluated with a comprehensive neuropsychological battery and additionally evaluated by brain perfusion radiopharmaceutical technetium-99m hexamethyl-propylene amine oxime (99mTc HMPAO). RESULTS:RRMS patients had hypoperfusion in several predefined Brodmann areas and lobes of the brain, relatively to demographically matched healthy controls according to an established normative database NeuroGam™. However, we noted blood flow reduction, mainly in the frontal lobes and other related prefrontal areas, involving both hemispheres, but with asymmetric left hemisphere predominance. Moreover, associations between measures of response inhibition, set shifting (executive functions) and severity of hypoperfusion in the left frontal lobes were also established. CONCLUSION:Cerebral hypoperfusion is an integral feature of MS pathology. Executive dysfunction is associated with robust cerebral perfusion deficits in the frontal and prefrontal cortex of cognitively impaired RRMS patients.

https://europepmc.org/abstract/med/30877732
Canadian Neurovascular Health Society
Research from Greece concludes “Cerebral hypoperfusion is an integral feature of MS pathology.” [Abstract only]

https://europepmc.org/abstract/med/30877732
Thursday, March 21, 2019 6:40 PM | CCSVI Alliance Volg link
"BOSTON—MRI scanners can map a person's innards in exquisite detail, but they say little about composition. Now, physicists are pushing MRI to a new realm of sensitivity to trace specific biomolecules in tissues, a capability that could aid in diagnosing Alzheimer's and other diseases. The advance springs not from improved scanners, but from better methods to solve a notoriously difficult math problem and extract information already latent in MRI data."

"Similarly, neurologists have long known that MS patients develop brain lesions in which myelin is lost. Using the new scans, Kolind has found that some MS patients lose myelin elsewhere in the brain, too, suggesting the loss precedes the lesions. Deoni and colleagues are studying myelin in 1200 healthy children over time to see how it develops with age. The data suggest social factors such as wealth can also lead to differences in myelination, Deoni says."
https://www.sciencemag.org/news/2019/03/clever-math-enables-mri-map-molecules-implicated-multiple-sclerosis-other-diseases?utm_campaign=news_daily_2019-03-20&et_rid=99137423&et_cid=2725816
Clever math enables MRI to map molecules implicated in multiple sclerosis, other diseases
New techniques wring subtle signals from data already produced by scanners
Thursday, March 21, 2019 4:14 PM | The Vascular Connection to Multiple Sclerosis shared a post. Volg link

Canadian Neurovascular Health Society
Research from Greece concludes “Cerebral hypoperfusion is an integral feature of MS pathology.” [Abstract only]

https://europepmc.org/abstract/med/30877732
Thursday, March 21, 2019 8:48 AM | Venöse Multiple Sklerose, CVI & SVI, CCSVI Volg link
Addressing Healing at the right (metabolic) level
Venöse Multiple Sklerose, CVI & SVI, CCSVI
Thursday, March 21, 2019 8:32 AM | Venöse Multiple Sklerose, CVI & SVI, CCSVI Volg link
Magnesium Deficiency, Inflammation & Pain

What causes pain?

Pain is related to inflammation, toxicity, cell wall rigidity, lack of ATP energy, mineral imbalances, or lack of enzymes and Magnesium, which is needed for 3751 enzyme reactions throughout the body (Human Magnesome: http://www.ncbi.nlm.nih.gov/pubmed/23095498 )! Dr. Mildred Seelig, magnesium researcher at the University of North Carolina stated that some experts estimate ~70% of cases involving muscle pain, cramps, and/or fatigue (labeled as fibromyalgia, migraine, CFS and constipation), are actually symptoms of magnesium deficiency.

Magnesium reduces cell wall rigidity

A Magnesium : Calcium ratio out of balance makes cell walls rigid because without enough Magnesium, Calcium doesn’t get assimilated in the bones, teeth etc. but dumped into body tissue (e.g. blood vessels, brain) where it NOT belongs to and cells don’t have enough ATP-energy either to pump Calcium out of cells again - The start of chronic inflammation & pain!

How Magnesium supplementation breaks down this circle of inflammation & pain?

Magnesium blocks pain reception. Increasing Mg concentration gradient between cell membranes and extracellular fluid => is blocking NMDA (N-Methyl-D-Aspartate) receptor and brings immediate pain relief! Have a look at this paper. http://www.ncbi.nlm.nih.gov/pubmed/2451020?dopt=Abstract&holding=npg

Therefore Magnesium is a powerful anti-inflammatory! It regenerates body tissue by increasing circulation => effects calcium-magnesium ratios positively => brings down inflammation => relieves muscle spasms (e.g. in blood vessels).
The human
BMC Bioinformatics. 2012;13 Suppl 14:S10. doi: 10.1186/1471-2105-13-S14-S10. Epub 2012 Sep 7. Research Support, Non-U.S. Gov't
Thursday, March 21, 2019 2:22 AM | Venöse Multiple Sklerose, CVI & SVI, CCSVI Volg link
Get properly tested & treat the CAUSE!
Venöse Multiple Sklerose, CVI & SVI, CCSVI
Thursday, March 21, 2019 12:46 AM | CCSVI Alliance Volg link
Thanks Avis Favarro -CTV for this link. Interesting study on early diagnosis of Parkinson’s.
https://www.ctvnews.ca/health/super-smeller-grandma-helps-researchers-identify-parkinson-s-odour-1.4343603
'Super Smeller': Grandma helps researchers identify Parkinson's odour
Researchers in the U.K. have been able to identify the specific compounds that make up an odour associated with people with Parkinson’s disease, thanks to the help of a grandmother who can smell the disease.
Wednesday, March 20, 2019 11:50 PM | CCSVI Alliance shared a post. Volg link
Thanks CNHS!
Canadian Neurovascular Health Society
Clinical trial, funded partly by the Belgian Charcot Foundation, for RRMS patients currently underway through the University in Brussels uses a drug (bosentan) approved to treat arterial cerebral hypertension by relaxing blood vessels. It is hypothesized that patients receiving the drug may show improvements to cerebral blood flow, mitochondrial function, fatigue, cognition, and mobility.

https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-019-3252-4
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