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Friday, August 17, 2018 4:31 AM | Venöse Multiple Sklerose, CVI & SVI, CCSVI Volg link
Copper and ceruloplasmin dyshomeostasis in serum and cerebrospinal fluid of multiple sclerosis subjects, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2018

“-An analysis of copper levels in serum and cerebrospinal fluid of Multiple Sclerosis patients is carried out.

-Ceruloplasmin, a peripheral marker of copper metabolism, is impaired in activity in Multiple Sclerosis subjects.

-A systemic state of high oxidative stress in MS subjects is observed.”

read more: https://www.sciencedirect.com/science/article/abs/pii/S0925443918300875
Venöse Multiple Sklerose, CVI & SVI, CCSVI
Friday, August 17, 2018 3:38 AM | Venöse Multiple Sklerose, CVI & SVI, CCSVI Volg link
No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases
By Douglas B. Kell et al, March 2018

Full paper: https://onlinelibrary.wiley.com/doi/full/10.1111/brv.12407
No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases - Kell - 2018 - Biological Reviews - Wiley Online Library
Thursday, August 16, 2018 11:31 PM | CCSVI Alliance Volg link
"Changes in expression profiles of internal jugular vein wall and plasma protein levels in multiple sclerosis"
https://molmed.biomedcentral.com/articles/10.1186/s10020-018-0043-4
Background
Multiple sclerosis (MS) is an inflammatory, demyelinating and degenerative disorder of the central nervous system (CNS). Several observations support interactions between vascular and neurodegenerative mechanisms in multiple sclerosis (MS). To investigate the contribution of the extracranial venous compartment, we analysed expression profiles of internal jugular vein (IJV), which drains blood from CNS, and related plasma protein levels.
Changes in expression profiles of internal jugular vein wall and plasma protein levels in multiple sclerosis
Thursday, August 16, 2018 8:03 AM | Venöse Multiple Sklerose, CVI & SVI, CCSVI Volg link
The role of magnesium in edema and blood brain barrier disruption, University of Adelaide 2011

Abstract
The blood-brain barrier (BBB) is constituted primarily of brain capillary endothelial cells and is a pre- requisite for the maintenance of brain homeostasis that is essential for optimal brain function. However, a variety of pathological conditions, such as sepsis, multiple sclerosis and epilepsia disrupt the BBB integrity and lead to the development of brain edema. Ionized magnesium (Mg2+) is a crucial cofactor that plays an essential role within the cell and regulates a variety of biochemical reactions. Changes in intra- and extracellular Mg2+concentrations influence the functions of cells and tissues. A growing body of evidence suggests that Mg2+plays a pivotal role in ameliorating BBB disruption via a number of mechanisms during certain neurological diseases. Systemic delivery of Mg2+ may constitute an alternative approach in the future, both to improve BBB integrity and to decrease brain edema in the course of a variety of diseases involving brain tissue.
full paper: https://www.ncbi.nlm.nih.gov/books/NBK507252/
Timeline Photos
Wednesday, August 15, 2018 10:34 PM | Venöse Multiple Sklerose, CVI & SVI, CCSVI shared The Vascular Connection to Multiple Sclerosis's post. Volg link
Changes in expression profiles of internal jugular vein wall and plasma protein levels in multiple sclerosis
Conclusions.....
The Vascular Connection to Multiple Sclerosis
Changes in expression profiles of internal jugular vein wall and plasma protein levels in multiple sclerosis
Conclusions
This study provides for the first time expression patterns of the IJV wall, suggesting signatures of altered vascular mRNA profiles in MS disease also independently from CCSVI. The combined transcriptome-protein analysis provides intriguing links between IJV wall transcript alteration and plasma protein expression, thus highlighting proteins of interest for MS pathophysiology.
https://molmed.biomedcentral.com/articles/10.1186/s10020-018-0043-4
FREE PDF: https://molmed.biomedcentral.com/track/pdf/10.1186/s10020-018-0043-4
Wednesday, August 15, 2018 9:37 PM | The Vascular Connection to Multiple Sclerosis shared MS Hope's video. Volg link
From Matt Embry:
I just received a message inviting me to attend the Multiple Sclerosis Society of Canada's "Burgers to Beat MS Day 2018" tomorrow.
I will not be attending. Not because I do not support raising funds for the MS Society of Canada, rather I believe this campaign is similar to buying cigarettes to support lung cancer research.
Below is a video we created a few years ago to address this perplexing issue. I think it is still relevant today.
#wakeup #endMS #thisisMS #christinesinclair
MS Hope
Matt Embry questions the alliance of the MS Society of Canada with fast food. What is going on at the MS Society of Canada?
Wednesday, August 15, 2018 8:19 PM | The Vascular Connection to Multiple Sclerosis Volg link
Changes in expression profiles of internal jugular vein wall and plasma protein levels in multiple sclerosis
Conclusions
This study provides for the first time expression patterns of the IJV wall, suggesting signatures of altered vascular mRNA profiles in MS disease also independently from CCSVI. The combined transcriptome-protein analysis provides intriguing links between IJV wall transcript alteration and plasma protein expression, thus highlighting proteins of interest for MS pathophysiology.
https://molmed.biomedcentral.com/articles/10.1186/s10020-018-0043-4
FREE PDF: https://molmed.biomedcentral.com/track/pdf/10.1186/s10020-018-0043-4
Changes in expression profiles of internal jugular vein wall and plasma protein levels in multiple sclerosis
Wednesday, August 15, 2018 4:24 PM | The Vascular Connection to Multiple Sclerosis Volg link
#BrainDrain matters
Impaired brain drainage in aging and Alzheimer’s
Researchers gained insights into how the waste clearing vessels in the brain change as mice age. The results suggests a possible way to combat the cognitive decline seen in aging and age-related diseases.
Tuesday, August 14, 2018 7:49 PM | CCSVI Alliance Volg link
"The Contribution of Extra Cranial Venous Drainage to Neuro-Inflammation in Multiple Sclerosis" - Paolo Zamboni -

Abstract
The role of the extracranial veins in the pathogenesis of inflammatory neurological/neurodegenerative diseases remains largely unknown and under-investigated. A condition named chronic cerebrospinal venous insufficiency (CCSVI) strikes the main extracranial veins and determines a slight increase in pressure up to the brain venules. The condition is linked with a recently-described chain of pathophysiologic events. Impaired CSF diffusion into the brain parenchyma between the peri-arterial and the perivenous spaces contributes to a worsened protein clearance. Furthermore, restricted venous outflow through the jugular veins reduces perfusion and the energy available to oligodendrocytes for myelin synthesis. Both peptide waste and myelin debris represent a strong chemotactic signaling. Increased transmural pressure in the CCSVI condition may also facilitate blood-brain barrier leakage and red blood cells extravasation. Consequently, iron stores are increased and likely linked to inflammation and degeneration. The contribution of the impaired venous function to neuroinflammation/degeneration warrants further studies in this direction.
CCSVI Alliance
Monday, August 13, 2018 2:57 PM | The Vascular Connection to Multiple Sclerosis Volg link
While we wait for the Kipnis Lab paper on #MS and #lymphatic flow, here's a review of the #BrainDrain veins.
A
We are living in very exciting times. During the past few years, researchers have changed what was thought to be known about the brain--spe...
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